Accelerating chemical exchange saturation transfer (CEST) MRI by combining compressed sensing and sensitivity encoding techniques
نویسندگان
چکیده
منابع مشابه
Blind Compressed Sensing-based Ultrafast Chemical Exchange Saturation Transfer (CEST) Imaging
CEST imaging, such as amide proton transfer (APT) imaging, is a novel, clinically valuable molecular MRI technique that can give contrast due to a change in water signal caused by chemical exchange with saturated solute protons. However, its clinical translation is still limited by its relatively long scan time because a series of RF saturation frequencies are unavoidably acquired. Here, we pre...
متن کاملSimplified and scalable numerical solution for describing multi-pool chemical exchange saturation transfer (CEST) MRI contrast.
Chemical exchange saturation transfer (CEST) imaging is sensitive to dilute labile proton and microenvironment properties such as pH and temperature, and provides vital information complementary to the conventional MRI methods. Whereas the Bloch equations coupled by exchange terms (i.e., Bloch-McConnell equations) have been utilized to quantify 2-pool CEST contrast, it is tedious to extend the ...
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The two glucose analogs 2-deoxy-D-glucose (2-DG) and 2-fluoro-2-deoxy-D-glucose (FDG) are preferentially taken up by cancer cells, undergo phosphorylation and accumulate in the cells. Owing to their exchangeable protons on their hydroxyl residues they exhibit significant chemical exchange saturation transfer (CEST) effect in MRI. Here we report CEST-MRI on mice bearing orthotopic mammary tumors...
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Introduction Both numerical simulation and analytical solution have been developed to describe CEST MRI phenomenon, which have aided our ability to quantify and optimize CEST imaging 1,2. In fact, a concise empirical solution has been proposed which decomposes CEST contrast as a product of the “ideal” contrast, saturation coefficient and spillover factor 3. However, the empirical solution is on...
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Target audience: Research scientists or clinicians who are interested in cancer metabolism, oxidative stress and redox state. Introduction/Purpose: Cellular redox state has been demonstrated as a key player in cellular biology. The disturbed balance of the redox state, such as excessive oxidative stress, can lead to many pathologic changes including cancer, heart diseases, neurodegenerative dis...
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ژورنال
عنوان ژورنال: Magnetic Resonance in Medicine
سال: 2016
ISSN: 0740-3194,1522-2594
DOI: 10.1002/mrm.26141